Wednesday, May 1, 2019

Photolabile Payloads? Yes Please!



https://pubs.rsc.org/en/content/articlepdf/2019/cc/c9cc02050k

To be fair, this is tagentially related to ADCs at best.  But it is also exceedingly cool technology.  The basic idea is to create a labile linker to a standard chemotherapy treatment that can be activated through the use of light shined on the tumor. 

The article describes lots of the issues, like the fact that tumors arent transparent.  But one can conceive of a way around that (long wavelengths), and could even see a world where these are targeted and internalized (here is where ADCs come in)

So in summary, it is three steps removed from being real.  But maybe this is something to watch out for in the 5th generation of ADC development?

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