Wednesday, May 15, 2019

A new potential cleavable linker?

Here is a new manuscript out of Georgia State University.  They have developed a click and release chemistry which can be applied to multiple payloads and released upon entrance into a particular cellular environment.

Click and Release: A High-Content Bioorthogonal Prodrug with Multiple Outputs

This could be very interested if you wanted to target the tumor microenvironment, and then used a mAb and a payload as your multiple prodrug attachments.  Happy reading.

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