Here is a new manuscript out of Georgia State University. They have developed a click and release chemistry which can be applied to multiple payloads and released upon entrance into a particular cellular environment.
Click and Release: A High-Content Bioorthogonal Prodrug with Multiple Outputs
This could be very interested if you wanted to target the tumor microenvironment, and then used a mAb and a payload as your multiple prodrug attachments. Happy reading.
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