Wednesday, May 15, 2019

A delivery paradigm beyond mAbs might be useful

Here is a nice review paper about targeted drug delivery. 
Managing efficacy and toxicity of drugs: Targeted delivery and excretion

However, they are not talking about mAbs as the vehicle.  This article is focused around physical drug delivery systems. I'll let the authors explain:
This review provides an essence of some newly developed simple but prospective strategies on enhancing the efficacy of drugs/bioactive molecules exploiting various drug delivery systems like micelles, cyclodextrins, liposomes etc. to serve the purpose of targeted delivery towards DNA, by endogenous and/or exogenous means. 
I think the coolest part though is the concept of adsorption and how these could potentially scrub the body of unwanted molecules.  Could this be applied to systematic free drug in order to decrease offsite toxicity? 

What do you think?

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