Bispecific Antibody Review

https://www.sciencedirect.com/science/article/pii/S0163725819300695#!

Here is a review paper out of the Netherlands about bispecific antibodies and their development.  This is an increasingly interesting direction for ADCs and there are already multiple different bispecific ADC constructs.

One bi-specific like molecule was MedImmunes 4276 HER2 bispecific, however, as presented at World ADC in London, there was significant unexpected issues owing to the complexity of the dual targeting nature of that molecule.  It was a little bit of a weird beast (https://www.ncbi.nlm.nih.gov/pubmed/26766593)
but still the lessons learned were that more complex doesn't always mean more better.

Happy reading